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doi: 10.2337/dci23-0048

[DOI] [PMC free article] [PubMed] [Google Scholar] 184.Liu Y., Tian Q., Yang J., Wang H., Hong T

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This process involves neural circuits modulated by neuropeptides, such as corticotropin-releasing factor.150 Dopamine plays a central role in mediating the immediate reinforcing effects of drugs, and dysregulation of the dopaminergic system has been proposed as a predisposing factor for chronic substance use and the maintenance of addiction.151 Dopaminergic neurons originating in the VTA project to the NAcc, amygdala, hippocampus, and prefrontal cortex, while those from the substantia nigra project to the dorsal striatum.152 The activation or disinhibition of VTA dopaminergic neurons is critical for the potentiation of alcohol, nicotine, and opioids.152 Cocaine exerts its effects by inhibits dopamine reuptake by blocking dopamine transporters, thereby increasing or prolonging synaptic dopamine concentrations.152 Other central nervous system stimulants elevate synaptic dopamine via mechanisms such as dopamine reuptake inhibition, reversal of dopamine transporter function, and promotion of dopamine release.153 However, the mechanisms by which GLP-1 receptor stimulation modulates dopaminergic function remain unclear

C., & Rodrigues, A

Axxams GLP-1 secretion assay: metabolic drug discovery from a different perspective Studies have shown that fatty acids and other endogenous ligands may engage with relevant GPCRs, including GPR40, GPR120, GPR119 and TGR5, to promote GLP-1 secretion