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We also expand on these findings by showing that KO of CNS GIPR can sensitize the response to GLP-1R agonism and that CNS GIPR is necessary for the maximal weight loss response to mGIPR-Ab/GLP-1

Proposals should be made to the corresponding author and will be reviewed by the Data Sharing Committee in discussion with the Chief Investigator

Understanding their individual mechanisms helps clarify why this pairing may offer enhanced therapeutic benefits

Participants experienced as much as 24 percent body weight loss at 48 weeks at higher doses

What are GLP-1RAs

examined the relationship between cannabinoid use and propofol requirements