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Glucagon-like peptide-1 (GLP-1) is a prominent gut-brain peptide predominantly secreted by preproglucagon (PPG) neurons within the NTS of the central nervous system (CNS) [20]

Abstract Aims Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are increasingly used to treat type 2 diabetes and obesity

Abbreviations AASLD: American Association for the Study of Liver Diseases APASL: Asian Pacific Association for the Study of the Liver BMI: body mass index CCR: C-C chemokine receptor CPGs: clinical practice guidelines CVD: cardiovascular disease EASL: European Association for the Study of Diabetes F: fibrosis FXR: Farnesoid X receptor GIP: glucose-dependent insulinotropic polypeptide GLP: glucagon-like peptide-1 HBV: hepatitis B virus HCV: hepatitis C virus HIV: human immunodeficiency virus HS: hepatic steatosis LOXL2: lysyl oxidase-like molecule 2 MAFLD: Metabolic dysfunction-associated fatty liver disease NAFLD: nonalcoholic fatty liver disease NASH: nonalcoholic steatohepatitis OCA: obeticholic acid PPAR: Peroxisome proliferator-activated receptors RCT: randomized controlled trial T2DM: type 2 diabetes mellitus TSH: Thyroid hormone receptor Declarations Acknowledgement This manuscript was supported in English editing from the research team of the Department of Medicine, Faculty of Medicine, Chulalongkorn University

Jin Metabolism.2025

For many women, this means years or even decades

Take our 5-minute clinical assessment The SELECT trial enrolled participants who were 84% white