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Beyond weight reduction, clinicians have observed improvements in metabolic health markers including fasting glucose levels, insulin resistance measures, and inflammatory biomarkers in treated youth

However, any new or worsening chest pain must be discussed with a doctor to rule out serious conditions

Contraindications It has been demonstrated that there is a possibility of developing medullary thyroid carcinoma in animal studies when on tirzepatide

In a randomized, double-blind, breast cancer prevention trial (NSABP P-1 trial), hot flashes (any severity, 80% vs 68%

PLoS ONE 8:116

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