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The remarkable commercial success of drugs like semaglutide and tirzepatide has created strong market momentum, driving significant investment in next-generation molecules and accelerating development cycles

This suggests a potentially better lean mass to fat mass loss ratio with tirzepatide but the trials used different populations and protocols so direct comparison requires caution

Moreover, depression is characterized by high prevalence of coexistence with many metabolic diseases, such as type 2 diabetes mellitus (T2DM) and obesity, and brain insulin resistance observed in both of these diseases is currently considered an important factor which may lead to the manifestation of depressive symptoms [10, 11]

only 45.9% of GLP-1 patients JAMA Network Surgery also yielded greater reductions in excess weight

J Clin Pharmacol 55: 497504, 2015
Eng hypothesized it might produce a hormone to modulate insulin for those big meals ( [78] ) ( [79] )
