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Dose reduction or discontinuation may be necessary if you develop: Persistent, intolerable gastrointestinal symptoms despite supportive measures Acute pancreatitis (discontinue permanently) Severe hypoglycemia, particularly if taking concurrent insulin or sulfonylureas Acute kidney injury or worsening renal function Gallbladder disease symptoms (abdominal pain, jaundice) Diabetic retinopathy complications (particularly with semaglutide) Severe hypersensitivity reactions including anaphylaxis or angioedema Pregnancy or plans for pregnancy (for semaglutide, discontinue at least two months before planned conception

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If your insurance covers weight loss medications, Ro can help you navigate the prior authorization process and potentially access brand-name medications at your insurance copay rate

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However, high levels of leptin from increases in fat tissue can cause leptin resistance, where the body isnt as responsive to the hormone