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For many patients, the health benefits are significant

What is especially interesting: the effect seems to go beyond weight loss A revised interpretation of the results suggests that the protective effects are partly independent of weight loss, it was therefore not only the participants weight loss that protected their hearts

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[DOI] [PMC free article] [PubMed] [Google Scholar] 105.Clements JN, et al

Improved oral bioavailability can reduce the dose burden, lower cost pressure, and reduce barriers for patients to start and maintain long-term peptide therapy.

Insulin has also been suggested to play a significant role as a paracrine regulator of glucagon secretion (the intra-islet hypothesis), although the mechanism by which this inhibition occurs is not well elucidated (133)