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By striving to reconcile the disparity between its considerable neuroprotective potential and recent clinical challenges, we can enhance our understanding of the potential role of semaglutide and other GLP-1 receptor agonists in combating cognitive decline

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Even the lower dosage groups, such as 4 mg, demonstrated measurable improvements in fasting glucose, insulin resistance, and HbA1c

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However, post-marketing surveillance through systems such as the MHRA Yellow Card Scheme suggests that taste changes may occur in some patients, though the exact frequency is difficult to quantify

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Materials and methods Search strategy This systematic review and meta-analysis were performed and reported in accordance with the Cochrane Collaboration Handbook for Systematic Review of interventions and the Preferred reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) [5] Statement guidelines

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