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[DOI] [PMC free article] [PubMed] [Google Scholar] 19.Jonklaas J, Bianco AC, Bauer AJ, Burman KD, Cappola AR, Celi FS, et al

Next, metabolic parameters after incretin agonist withdrawal were examined to determine the extent of improvement of metabolic dysfunction 33

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Metformin has, for example, been shown to have direct effects on inflammation, including effects on NF-B signalling and differentiation of monocytes into macrophages [52, 53], as well as suppressing proinflammatory cytokines from these macrophages