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However, the targets of both phase 1 and phase 2 trials are diverse, with a noticeable increase in the number of phase 1 trials focusing on neuroprotection and phase 2 trials focusing on anti-neuroinflammation [85]

The current understanding points to a potential biphasic pattern in GLP-1 RA studies, where any observed early worsening may be related to rapid glycemic improvement rather than direct retinal toxicity, particularly in patients with pre-existing retinopathy, poor glycemic control, and those undergoing HbA1c reduction 47

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