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Benefits Significant, clinically proven weight loss Reduced risk of Type 2 diabetes, high blood pressure, and cardiovascular disease Non-surgical, once-weekly injection Personalized dosing not a one-size-fits-all approach Physician-supervised by a board-certified plastic surgeon Built-in path to body contouring if needed after weight loss Best candidates for GLP-1 weight loss injections GLP-1 type medications are suitable for adults who: Have a body mass index (BMI) of 30 or higher (obesity) Have a BMI of 27 or higher (overweight) with at least one weight-related condition, such as type 2 diabetes, high blood pressure, or high cholesterol

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[1] [2] The liver is involved in the metabolism of the peptide structure, but significant hepatic impairment does not dramatically alter elimination times

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AMG 133 (maridebart cafraglutide) is a bispecific molecule engineered by conjugating a fully human monoclonal anti-human GIPR antagonist antibody to two GLP-1 analogue agonist peptides using amino acid linkers