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In the ACHIEVE-3 head-to-head against oral semaglutide in T2D, 36 mg orforglipron produced about 9.2% body weight reduction versus about 5.3% on 14 mg oral semaglutide, and superior HbA1c reduction

Monitor your mental health closely and speak with your doctor if you notice persistent changes in mood, energy or wellbeing

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Predictive Characteristics : Patients likely to see the best outcomes are typically younger with milder obesity and exhibit specific physiological traits such as high loop gain and severe upper-airway collapsibility

These results are sustained long-term too, with 10.2% average weight loss maintained at four years when consistently using the medication

doi: 10.1038/s41591-025-04102-x