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Moreover, in the SURPASS-4 trial, subjects at high cardiovascular risk, including (but not limited to) those with coronary artery disease, cerebrovascular disease, or congestive heart failure, were assessed for the occurrence of MACE

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Ultimately, this data aligns with conclusions from regulatory bodies like the FDA, which, after its own review, stated it has "not found evidence that use of these medications causes suicidal thoughts or actions." Takeaway 3: Who Was Studied Matters, A Critical Caveat While the results are broadly reassuring, it is crucial to understand who was included in these trials