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Clinical trials show average weight loss of 15-22% of body weight on semaglutide 2.4 mcg weekly over 68 weeks, though individual results vary widely

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While numerous preclinical and clinical studies have demonstrated that GLP-1 can access various nuclei associated with energy homeostasis and hedonic eating in the CNS via bloodbrain barrier (BBB), research on the activity of SGLT-2is remains limited

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Multiple formulations

This creates a safe target and is especially helpful for leaner individuals where the fat layer is thin