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doi: 10.1111/dom.13838 25

Second-generation oral semaglutide, whose bioavailability and safety have been significantly improved by the application of new excipients and formulation optimization, but its gastrointestinal side effects are still obvious (Nielsen et al., 2025)

An additional 4mg yielded only 1.4 percentage points of additional weight loss, while side effects increased notably

These medications work by improving insulin sensitivity and curbing appetite, which often leads to noticeable weight loss - a critical factor in addressing many PCOS-related challenges

By activating glucagon-like peptide-1 (GLP-1) receptors, retatrutide stimulates insulin secretion and inhibits glucagon release, leading to improved blood sugar control
