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In a Phase 2 trial published in the New England Journal of Medicine in 2023, participants lost up to 24.2% of their body weight over 48 weeks

On this basis, the treatment options for obese HFpEF patients have transitioned towards metabolism-focused therapeutic strategies

In the early weeks and at lower doses, semaglutide may not fully suppress appetite
See if GLP-1s are a possible option for you

Doctors say painful side effects, high treatment costs and inconsistent insurance coverage have kept GLP-1s away from most obese youths

While Metformin improves insulin sensitivity and helps control appetite, GLP-1 medications (like semaglutide or tirzepatide) slow digestion and enhance feelings of fullness
