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For many women in midlife, menopause brings a host of unwanted physical changes, including weight gain and more abdominal fat

Nausea leads the list, and some people also get vomiting, diarrhea, constipation, or stomach discomfort

For instance, clinical trials on pancreatitis rarely include individuals with a history of heavy alcohol consumption

Obes Surg 2003

At therapeutic doses, typically 10 to 25 milligrams taken three times daily, it is generally well-tolerated and effective for mild to moderate nausea

Du 2024 Phase 2 Trial Results: What the Early Data Showed Phase 2 trials of retatrutide showed dose-dependent weight loss reaching 24.2% at 48 weeks with the 12 mg dose, a result that outperformed anything previously recorded for a pharmacological agent at that timepoint