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Heterogeneity and similarities in GLP-1 receptor agonist cardiovascular outcomes trials

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We included all individuals who initiated a combination of metformin and GLP-1 RA or metformin and DPP-4i treatment between January 1 st 2007 and December 31 st 2018

GLP-1 receptors are present in both the liver and adipose tissue, and activation of these receptors by GLP-1 agonists can lead to a reduction in adipose tissue inflammation and an increase in adiponectin secretion, and both can, in turn, have a positive impact on the liver [27]

Give it at least 4-8 weeks of consistent use before evaluating results

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