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No randomised controlled trials have demonstrated efficacy in reducing disease activity or joint inflammation, and existing evidence consists only of preclinical studies and theoretical mechanisms

Hu was one of the California Optometric Associations Young ODs of the Year in 2023

First, let me caution that this is just a mouse study, so it may not hold true in humans
4 Regulation of intestinal microbiota by metformin 4.1 Overview Metformin comes from Galega officinalis L., and later the function of lowering blood glucose has been found in animals, and more and more studies on its hypoglycemic effect have been conducted, and the effect has been furtherly confirmed

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In addition to GLP-1 in tissues, we used ELISA to detect the level of GLP-1 in serum, and its trend was also consistent with that of GLP-1 in pancreas and intestine (Figure 3E)
