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Within the hypothalamus, Gipr- expressing cells are localized in the paraventricular, dorsomedial and arcuate nuclei and colocalize with markers for neurons, glia and vascular cells

The cells were exposed to a range of treatments: TGF-1 (10 ng/ml, R&D Systems Inc., Minneapolis, USA), IL-1 (10 ng/ml, R&D Systems Inc., Minneapolis, USA), MCC950 (10 M, Selleck, Houston, TX, USA), 3PO (10 or 30 M, Selleck, Houston, TX, USA), liraglutide (10, 100 or 1000 nM, Selleck, Houston, TX, USA), and sodium L-lactate (20 mM, Sigma-Aldrich, St
4 They also induce satiety by activating GLP-1 receptors in brain centers that regulate appetite, such as the hypothalamus, brainstem nucleus tractus solitarius, and amygdala 5 , and slow gastric emptying, which aids in glycemic control and weight loss

These treatments significantly reduce urinary albumin excretion, lower SBP, and improve HbA1c levels

doi: 10.2337/db11-0979 36 SarsonDLWoodSMKansalPCBloomSR