glp-1 kidney protection agonists in the treatment of chronic disease in type 2 diabetes and obesity Renal effects of GLP-1 receptor

We see absolutely no short-term impact on our results. Moreover, even using the most optimistic forecast, we believe the impact will be very modest to our volumes in our categories, speculated Van de Put, who has nevertheless dedicated a special work stream to stay close to the issue

doi: 10.1136/rmdopen-2024-004314

Side effects are most pronounced during dose escalation and tend to improve at each dose level as the body adapts before the next increase

It was the biggest step forward in weight management in decades

In the meantime, mitochondrial dysfunction is induced by hepatic IR and lipid accumulation and the lipid peroxidation mediated by cytochrome p450 2E1 boost the production of reactive oxygen and promote the degradation of mitochondria (125), which could further lead to the lack of cellular energy and metabolic intermediates accumulation, all these may lead to the secretion of pro-inflammatory cytokines, hepatocellular apoptosis and hepatic fibrogenesis, finally resulting in cirrhosis of the liver (125) ( Figure 3 )

Sometimes, non-event experiences were reported with no noticeable effects