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12 Besides setmelanotide, which is indicated for patients with rare genetic forms of obesity, these alternative anti-obesity medications result in modest weight loss, typically ranging from 3 to 9% of baseline body weight

A true microdose involves taking an amount below the labeled starting dose, such as 0.1 mg or 0.125 mg of semaglutide

Semaglutide (Wegovy) followed with stronger efficacy data

Patients with higher baseline hemoglobin A1c levels (above 9%) typically experience more rapid and pronounced glucose reductions compared to those with A1c levels closer to target

Diabetes Care (2015) 38(2):26470

Efficacy and safety of LixiLan, a titratable fixed-ratio combination of lixisenatide and insulin glargine, versus insulin glargine in type 2 diabetes inadequately controlled on metformin monotherapy: the LixiLan Proof-of-Concept Randomized Trial