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Its Brand Partner system contributes to perceptions of MLM-style promotion, though it is not formally classified as such

Nature Medicine, 28(10), 20832091.
Even as the intensity may diminish slightly, the ongoing effects of reduced hunger and cravings remain, helping patients stick to a calorie-controlled diet

These patients often have leptin resistance or blunted satiety hormone signaling, meaning their brains don't receive adequate fullness signals from normal eating
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The evidence is still early, drawn from lab models rather than clinical trials on human skin