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There have also been supply constraints as off-label demand for weight-loss use exploded

Who tends to be considered a candidate Phase 2 trial inclusion criteria focused on adults with a body mass index of 30 kg/m or higher, or 27 kg/m or higher with at least one weight-related comorbidity (such as hypertension, dyslipidaemia, obstructive sleep apnoea, or cardiovascular disease)

That 10% difference sounds small until you realize it translates to preserving an extra 1-2 kg of lean tissue over a typical weight loss period

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*Agenda may be adjusted based on course requirements and operational considerations

Five participants withdrew from the trial, including four in the placebo arm (two participants did not provide a reason for withdrawal, one participant did not have a weight loss response, and the remaining participant withdrew due to adverse event (AE) reasons)