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If possible, they should use the same media (video format), using the same time duration and with the same frequency as the Oprah Special. The company must respond with an explanation and provide supporting materials if it disagrees with any of the FDA regulation violations identified in the warning letter

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Safety & Tolerability: Semaglutides side effect profile is similar to other GLP-1 RAs: GI disturbances (nausea in ~20% of patients initially, vomiting ~10%, diarrhea ~10%)

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But it is not impossible, especially for certain populations

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Overall, reviewers who approach Patchie with a realistic mindset tend to rate it highly for comfort, subtle support, and the absence of harsh side effects

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