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Press release, December 11, 2025

[DOI] [PMC free article] [PubMed] [Google Scholar] 76.Russo G., Piscitelli P., Giandalia A., et al

doi: 10.1056/NEJMoa1008862 3 HolmanRRPaulSKBethelMAMatthewsDRNeilHA

Chronic stress reduces the appetite-suppressing effectiveness of GLP-1s, and perimenopausal estrogen decline dysregulates the HPA axis that cortisol and GLP-1 mechanisms share, raising baseline cortisol

Mohan, a diabetologist and researcher who was not involved in the study, said the results, while not entirely unexpected, are significant

Strength training also supports metabolic regulation, since muscle tissue is metabolically active
