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For significant weight loss (50+ pounds) If your goal involves losing 50 or more pounds, the appetite suppression timeline with retatrutide is actually encouraging

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I was sitting at 238 pounds, she was around 186

The inhibitory effect of GLP-1R agonists on food intake has been demonstrated in a number of species, including non-human primates [54] and humans [55]

Contact your GP if you experience these symptoms, as neurological damage from B12 deficiency can become irreversible if left untreated

However, this can lead to side effects like nausea or constipation