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It binds to GLP-1 receptorsG proteincoupled receptors widely distributed in pancreatic -cells, gastrointestinal smooth muscle, the central nervous system, heart, kidney, adipose tissue, and reproductive organs

In addition, GLP-1R overexpression results in improved cognitive function in mice and GLP-1R knockout severely impairs cognitive ability (5, 117, 118)

These side effects are most frequent during the initial weeks and when increasing the dose but tend to improve over time

Understanding the cardiovascular profile of GLP-1 agonists is essential for both prescribers and patients, particularly given the metabolic conditions they are used to treat often carry inherent cardiovascular risk

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