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Last month, Eli Lilly reported Phase 3 trial results showing that orforglipron 36 milligrams lowered A1c blood sugar levels by 2.2% compared with 1.4% for oral semaglutide 14 mg, the active ingredient in the diabetes pill Rybelsus and in the injectable drugs Ozempic and Wegovy

Lower use among those ages 65 and older (9%) likely reflects Medicares lack of coverage for drugs prescribed specifically for weight loss

Dehydration: Gastrointestinal side effects can lead to dehydration, another culprit behind fatigue

Companies developing high-quality biosimilar GLP-1 therapies with competitive pricing and proven bioequivalence will democratize access while capturing significant market share in cost-sensitive segments

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Like human GLP-1, Saxenda regulates appetite and lowers body weight through decreased food intake