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What has changed is our ability to harness them clinically, to deliver specific signals to specific systems and produce outcomes once reserved for the realm of aging gracefully and hoping for the best

For obesity in particular, these medicines clearly work but are expensive, and it is illogical to say that we try to fix our obesity crisis with medicines taken indefinitely to supress ones appetite, without tackling the social, financial and environmental aspects that are driving obesity in the first place

The phase 3 trials now underway will help demonstrate how the drug performs over longer periods and in larger, more diverse populations of patients

PMID: 34459213 DOI: 10.1161/CIRCULATIONAHA.121.056824 Packer M et al (2022): Critical Reanalysis of the Mechanisms Underlying the Cardiorenal Benefits of SGLT2 Inhibitors and Reaffirmation of the Nutrient Deprivation Signaling/Autophagy Hypothesis

Although efficacy has been documented for weight-loss medications compared to placebo-subtracted weight loss, it is important to consider there is a wide range of weight loss reported in studies among these medications

EVs are essential mediators of microglia-astrocyte interaction