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Description

Patients with primarily subcutaneous fat accumulation on the abdomen, hips, and thighs may see modest improvement in body composition but should not expect the same degree of change that someone with significant visceral fat load will experience

All existing research has been conducted in mice, with no long-term human safety trials and no established safe doses for humans

The first co-primary endpoint reported no statistically significant difference in the change in 6MWD with acoramidis compared to placebo (LS mean change, -26.51 meters versus -24.54 meters, respectively) at 12 months

GLP-1 secretion is stimulated by nutrient intake and exerts its effects on glucose homeostasis by stimulating insulin secretion, gastric emptying confiding the food intake, and -cell proliferation

Patients should be advised to seek urgent same-day medical attention (via NHS 111, 999 or A&E) if they experience: Severe, persistent abdominal pain with or without vomiting (potential pancreatitis) Signs of severe allergic reaction Patients should also contact their healthcare professional promptly if they experience: Unexplained weight loss beyond expected therapeutic effect Worsening of autoimmune disease symptoms Persistent gastrointestinal symptoms affecting nutrition or hydration Suspected adverse reactions should be reported via the MHRA Yellow Card scheme (yellowcard.mhra.gov.uk or the Yellow Card app)