is tirzepatide a glp-1 agonist Major physiological roles of and GIP. acting as an What Is Tirzepatide and How

Its important action is the stimulation of insulin secretion through binding to GLP-1R on pancreatic cells

The metabolic improvements associated with GLP-1 agonist therapyincluding weight loss, improved glycaemic control, and potential benefits in MASLD (formerly known as non-alcoholic fatty liver disease)could address multiple health concerns simultaneously, though effects specifically in alcohol-related liver disease are not established

DOI.org (Crossref) , Chedid, V., et al

GLP-1 may exert its effects locally via the vagus nerve before being degraded by DPP-4 in circulation

Lancet 400 , 18691881 (2022)

Mild to moderate transient gastrointestinal side effects were the most frequently reported adverse events associated with tirzepatide treatment and were similar in frequency and intensity compared to semaglutide (nausea 17%22% vs