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Semaglutide and tirzepatide do not directly cause muscle wasting

Subsequent studies then confirmed the presence of GLP-1R in these and other insulinoma cell lines [[369], [370], [371], [372], [373], [374], [375], [376]] as well as in somatostatin-secreting cells [370,375] and in islets isolated from rats [377] and humans [378]

Advances in Experimental Medicine and Biology , 1328

Sustainable results still depend mainly on healthy eating, regular physical activity, long-term lifestyle changes and following medical treatment, if needed

Moreover, the authors showed that bone marrow transplant using wild-type mice donors normalized expression of multiple genes regulating immune function and epithelial integrity