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The tolerability signal also sets up a combination narrative with incretins, where the objective is additive efficacy without stacking overlapping adverse events or forcing higher GLP-1 dosing that drives discontinuations

PMID: 40675357

[2, 4, 5] How our environment influences obesity If our genetics haven't changed since the 1900s, is the environment to blame for the rise in obesity

[DOI] [PubMed] [Google Scholar] 123.Swafford D., Shanmugam A., Ranganathan P., Hussein M.S., Koni P.A., Prasad P.D., Thangaraju M., Manicassamy S

Others are used to prevent cardiovascular events (like heart disease and high blood pressure) in people with type 2 diabetes

The ASCO GI 2026 data suggest that GLP-1 therapy may be particularly relevant for metabolically high-risk populations, including individuals with obesity, insulin resistance, or type 2 diabetesgroups that now account for a substantial proportion of colorectal cancer burden