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Preclinical data supporting the immunoregulatory role of miR-30d-5p strengthen these observations

revealed that the rates of neuropathies leading to first/recurrent amputation within 30 years were higher in patients receiving glimepiride 8 mg/day (N=248) than in patients receiving liraglutide 1.2 mg/day (N=251) or liraglutide 1.8 mg/day (n=247), while they were numerically similar between patients receiving liraglutide 1.2 mg/day and liraglutide 1.8 mg/day

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The coexistence of CKD triples the risk of cardiovascular (CV) death compared to T2D alone, highlighting a critical intersection of metabolic and renal pathophysiology [9]