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Tirzepatide is the closest competitor, producing about 25% weight loss over 88 weeks

Clinical trials reveal that up to 39% of weight lost on GLP-1 therapy comes from lean muscle mass rather than fat

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However, whilst intracellular Ca 2+ is undoubtedly a physiologically important response in electrically excitable cells such as beta cells and neurons, it is unclear how well this is replicated by measuring responses in nonexcitable cells, due to cellspecific differences in the mechanisms underpinning Ca 2+ dynamics

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For example, butyrate producing bacteria and Akkermansia are decreased in type 2 diabetes mellitus patients 2