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Contraindications Personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2

Read this doctor-reviewed guide on results, cost, side effects, and which injection suits you best.

Poddar S et al

Twenty-pound weight loss on semaglutide typically occurs over 46 months in clinical trials, though individual timelines vary widely based on baseline metabolic factors, adherence, and dose titration

See regulations on who can prescribe semaglutide in all 50 states.

Research on the experimental drug petrelintide suggests it is much less likely to cause nausea and vomiting than GLP-1 drugs, but the pace of weight loss is more moderate.