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Oral semaglutide GLP-1 RAs were developed as injectable therapies for type 2 diabetes because absorption of a polypeptide from the gastrointestinal tract after swallowing was considered unfeasible, as the strongly acid environment and action of peptidases in the stomach rapidly lead to its breakdown

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Diabetes Research and Clinical Practice, 183 , Article 109119
Additional information Communicated by Massimo Federici, M.D