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Abbreviations ASCVD: Atherosclerotic cardiovascular disease BMI: Body mass index CI: Confidence interval CKD: Chronic kidney disease CVD: Cardiovascular disease eGFR: Estimated glomerular filtration ratio GLP-1RA: Glucagon-like peptide-1 receptor agonist HFpEF: Heart failure with preserved ejection fraction HFrEF: Heart failure with reduced ejection fraction HHF: Heart failure hospitalization HR: Hazard ratio LDL: Low-density lipoprotein LVEF: Left ventricular ejection fraction MACE: Major cardiovascular events MRA: Mineralocorticoid receptor antagonist SGLT2: Sodium-glucose cotransporter 2 References Wong ND, Sattar N

The NIDA Research Technology Branch provided active cannabis and placebo for this study

Benefits of GLP1 drugs (Source: Everyday Health) Unintended Consequences: Muscle Loss While GLP-1 therapies have demonstrated remarkable efficacy in weight reduction, recent clinical trials have highlighted a concerning side effect: significant loss of lean muscle mass

Generally, the increase in heart rate with GLP-1 receptor agonists is small but clinically relevant as heart rate is a marker of cardiovascular disease [97]

Instead, it may be part of a natural shift in how the body responds to ongoing weight loss