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Relative Contraindications (Use with Caution): Severe renal impairment (eGFR below 30), diabetic retinopathy, severe gastroparesis, history of gallbladder disease, concurrent use of insulin or sulfonylureas (hypoglycaemia risk)

Nursing Mothers Sitagliptin is secreted in the milk of lactating rats at a milk to plasma ratio of 4:1

A recent study suggests that the use of GLP-1 receptor agonists was associated with better outcomes compared with the use of DPP-4 inhibitors among patients with type 2 diabetes and advanced-stage chronic kidney disease

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