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Before asking participants about their expectations for the drugs impacts on the food system, all participants were given a brief background on the topic, which said: GLP-1 drugs decrease users appetite, which results in fewer calories consumed

Who Should and Should Not Consider GLP-1 Therapy With Crohn's Disease Candidates for GLP-1 therapy with Crohn's disease typically have well-controlled or remission-stage disease, stable inflammatory markers, adequate nutritional status, and documented need for weight management

Liraglutide specifically has been shown to increase heart rate by 2.71 bpm (95% CI: 1.45-3.97) compared with placebo and 2.49 bpm (95% CI: 1.77-3.21) compared with active controls

Additionally, females experienced greater pain relief than males, suggesting a potential gender-specific response to the treatment [62]

Despite lower efficacy and tolerability shown by nasally administered PYY agonists in early studies, long-acting subcutaneous PYY receptor agonists such as PYY 1875 are undergoing early-phase clinical trials to evaluate their safety and effectiveness as monotherapy or in combination with GLP-1 receptor agonists for the treatment of obesity

However, all included studies enrolled adult participants, precluding analyses in pediatric or adolescent populations