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GLP-1 weight-loss drugs with semaglutide were associated with a lower risk of depression, anxiety, substance use disorders, and self-harm, according to a new study.

It highlights the PIONEER clinical trial programme results, and reviews the efficacy, safety and tolerability.

Obesity pharmacotherapy from the @TheAACE diabetes algorithm: GLP1/GIP and GLP1 RAs produce ~1020% weight loss with A1c reduction, while older agents like phentermine, orlistat, and naltrexone/bupropion have less efficacy and safety tradeoffs

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