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The following information is discussed to educate patients on realistic weight loss expectations/ Semaglutide (Ozempic) is used to treat T2DM

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Not every patient is an appropriate candidate for GLP-1 therapy, regardless of demand

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The genetic test reveals predispositions in peptide signaling pathways, not exact medication response or guarantees of weight loss

Further supporting a cardiometabolic role of GLP-1 (9-36amide), both GLP-1 (7-36amide) and GLP-1 (9-36amide), but not exendin-4, promote vasodilation in isolated and ex vivo cultured mesenteric blood vessels [201], i.e., the vasodilatory effect of GLP-1 (7-36amide) was not different relative to that of GLP-1 (9-36amide) and was likewise preserved in GLP-1R KO mice [201]