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Freezing causes ice crystal formation that physically disrupts the molecular structure, making the medication potentially unsafe to use

63 , 12561272 (2003) Bailey, R

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doi:10.1136/bmjopen-2023-083550 Dumolt JH, Rosario FJ, Kramer AC, Horwitz S, Powell TL, Jansson T

Occasional light alcohol use may be tolerable for some patients, particularly after the first 812 weeks of treatment

These symptoms typically resolve within 2 to 3 weeks at each new dose level