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Across our case studies for these drugs, we observe the following trends: Patent Term Extensions: Statutory Patent Term Adjustment (PTA) and Patent Term Extension (PTE) mechanisms delay the entry of generic medicines and add billions in additional revenue for blockbuster 2 drugs, even before accounting for any extended market monopoly as a result of follow-on patenting

Short sleep duration is also linked with an increased risk of obesity

These might include gastro-oesophageal reflux (which is a recognised side effect), changes in eating patterns, or indirect effects related to the medication's impact on gastrointestinal function

Gallstones (cholelithiasis) or inflammation of the gallbladder (cholecystitis) can present with pain in the right upper quadrant that may radiate to the back or right shoulder, often accompanied by nausea and sometimes fever or jaundice