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As with any medication, GLP-1 receptor agonists like semaglutide may cause side effects

Wegovy in a Pill Now Available in Iowa Posted on January 8, 2026 at 2:33 PM by Iowa Weight Loss Specialists For years, GLP-1 medications like Wegovy have helped patients achieve meaningful weight loss, but injections were the only option

However, the test for subgroup differences was not significant ( p = 0.34), suggesting that while tirzepatide showed a greater numerical benefit, the difference between the drugs was not statistically robust, likely due to the dual agonist mechanism

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For example, in the lateral hypothalamus exendin-4 is less potent at inducing anorexic downstream mediators like neurotensin or IL-6 and at suppressing downstream orexigenic mediators (eg, orexin) when tested in estrous cycle phases in which estrogen levels are low (33, 47)

it could have microbial contamination, like bacteria, mold or fungus
