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Moreover, downregulation of GLP-1R level is also found in the glomerular endothelial cells of diabetic mice, which may be due to increased GLP-1R degradation resulted from diabetes-induced PKC2 activation 28

This work was supported by grants from the Fondo Concursable de Investigacin 570609, Departamento de Tecnologa Mdica, Universidad de Chile (PC), ANID scholarship 21253303 (AP-H), ANID/FONDECYT 3240492 (MT), ANID/FONDECYT Grants 11251042 (ES-P), 11221017 (YH-F) and ANID/Basal FB210024 (YH-F)

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CagriSema achieved 22.7% in 68 weeks

DOI: 10.3389/fcdhc.2023.1293926