glp-1 agonists diabetes Understanding receptor and their impact on drug discovery Schematic illustration of monoagonists, dual
Description
R.MackowskiM

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Attenuation of High Glucose-Induced Rat Cardiomyocyte Apoptosis by Exendin-4 via Intervention of HO-1/Nrf-2 and the PI3K/AKT Signaling Pathway

The mechanism is straightforward: GLP-1 RAs enhance glucose-dependent insulin secretion, and stacking that on top of glucose-independent insulin release from exogenous insulin or sulfonylureas removes the glucose-dependent safety brake

H.Foster-DaviesH.SalemA.HooleA

The fasting C-peptide increase reflects substantial intact pancreatic beta-cell reserve to produce insulin
