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Growth differentiation factor 8 (GDF8)/myostatin, acting via ActRIIA/B receptors, is the best-characterized negative regulator of muscle mass, leading to therapeutic efforts to augment muscle growth by blocking GDF8 or ActRIIA/B

Animal models have shown that prenatal and postnatal exposure to androgens can lead to enlargement of adipocytes, accumulation of visceral fat, and decreased insulin sensitivity in women [60, 61]

Treatment of obesity and diabetes using oxytocin or analogs in patients and mouse models

In its original iteration, the company offered its customers a whole-body approach to managing weight that combined nutrition, sleep, movement, and stress management, among other holistic means of self-care