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The physiological actions of GLP-1 include stimulation of glucose-dependent insulin secretion, inhibition of glucagon release, slowing of gastric emptying and the promotion of satiety, contributing to both reducing glycaemic levels and weight loss

A summary of clinical trials to include drug, dosing strategy, sample size, primary outcome measurements, risk reduction, date of publication, and conclusions is found in Table 1 [103,104,105,106,107,108,109,110,111,112]

Tracking when ANDA approvals move from tentatively approved to final approved status a status change that often coincides with patent expiry or litigation resolution and immediately precedes commercial launch

Kahl S, Gancheva S, Strassburger K, Herder C, Machann J, Katsuyama H, Kabisch S, Henkel E, Kopf S, Lagerpusch M, Kantartzis K, Kupriyanova Y, Markgraf D, van Gemert T, Knebel B, Wolkersdorfer MF, Kuss O, Hwang JH, Bornstein SR, Kasperk C, Stefan N, Pfeiffer A, Birkenfeld AL, Roden M

In the second trial, SURPASS-2, tirzepatide administered at doses of 5 mg, 10 mg, or 15 mg showed superior efficacy compared to semaglutide (1 mg) in reducing body weight and HbA1c levels over 40 weeks in patients with T2DM inadequately controlled with metformin [66]

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